Review on Identification of Major Infection Site and Disease Progression Pathway for Early Detection of Novel Corona Virus (Covid-19)

Manohari M. Wickramaratchi, Alexander Pieris , Shehan W. S. A. J. Fernando

Life Sciences Research Centre Sri Lanka, Subuthipura, Battaramulla 10120, Sri Lanka

The Novel Coronavirus disease, COVID-19, is a new highly contagious infection, transmitted from human to human of pandemic proportion. The number affected is increasing dramatically, without specific therapy nor vaccination available. The major challenges for its epidemiological control include the prolonged incubation period without symptoms and its ability to transmit the disease by both symptomatic and asymptomatic. This review is to bring awareness to the scientific and medical community and highlight a major route of infection during incubation period, suggesting a new diagnostic approach to be adopted. Exploration of this study may unfold a unique approach to the early detection and clinical management well before its progression to severe disease manifestation. We highlight the importance of evaluating pancreatic function, hepatocellular changes and gastrointestinal lining to enable early diagnosis of the disease.